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Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset
Li Wan1, Jingyong Huang2, Haizhen Ni3
1Department of pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC Cardiovascular Disorders
|February 15, 2018
Summary
Researchers identified key genes like CCR7 and NELL2 involved in abdominal aortic aneurysm (AAA) pathology. These genes show diagnostic potential for this high-mortality cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Genomics
- Biomarker Discovery
Background:
- Abdominal aortic aneurysm (AAA) is a prevalent cardiovascular disease associated with significant mortality.
- Identifying specific genes for AAA diagnosis and treatment is crucial.
Purpose of the Study:
- To identify novel diagnostic and therapeutic gene targets for abdominal aortic aneurysm (AAA).
Main Methods:
- Differential gene expression analysis of mRNA data from AAA and normal individuals.
- Gene Ontology, KEGG pathway, TF, and PPI network analyses.
- Immunohistochemical staining and ROC analysis for validation and diagnostic value assessment.
Main Results:
- 1199 differentially expressed genes (DEGs) were identified between AAA and normal groups.
- Enriched pathways included vascular smooth muscle contraction and cancer pathways.
- NELL2, CCR7, MGAM, HBB, CSNK2A2, ZBTB16, FOXO1, and PDGFA were identified as potential diagnostic biomarkers for AAA.
Conclusions:
- The identified genes, including NELL2 and CCR7, are potentially implicated in the pathogenesis of AAA.
- These genes may serve as valuable diagnostic markers for AAA.
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