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Published on: May 25, 2022
In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
Laure Stapert1, Cindy Wolfe1, Dean Shinabarger1
1Micromyx, Inc., Kalamazoo, Michigan, USA.
Abstract:
Omadacycline (OMC), a broad-spectrum aminomethylcycline, has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections. Here, the in vitro activity of OMC against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 μg/ml against Bacteroides spp., 0.5 μg/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica, 1 μg/ml against Peptostreptococcus spp., and 16 μg/ml against Clostridium perfringens.
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