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Multisensory Integration Enhances Temporal Coding in Ventral Cochlear Nucleus Bushy Cells.

Amarins N Heeringa1, Calvin Wu1, Susan E Shore2,3,4

  • 1Kresge Hearing Research Institute, Department of Otolaryngology.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 15, 2018
PubMed
Summary

Multisensory integration enhances auditory processing. Stimulating the somatosensory system alongside sound improves temporal coding in auditory neurons, potentially aiding communication signal perception.

Keywords:
bushy cellsmultisensorysound codingtemporal codingventral cochlear nucleus

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Area of Science:

  • Neuroscience
  • Auditory System
  • Sensory Integration

Background:

  • Temporal coding of auditory stimuli is vital for processing communication signals.
  • Bushy cells in the ventral cochlear nucleus are key output neurons for auditory information.
  • Bushy cells receive somatosensory input, suggesting a role for multisensory integration in auditory perception.

Purpose of the Study:

  • To investigate the role of multisensory integration in temporal coding within bushy cells.
  • To examine how activating the spinal trigeminal nucleus (Sp5) affects bushy cell responses to auditory stimuli.

Main Methods:

  • Recorded single unit responses of bushy cells to amplitude-modulated (AM) noise in guinea pigs.
  • Compared responses during auditory-Sp5 stimulation (bimodal) and 45 minutes after.
  • Used anterograde labeling to trace Sp5 projections to bushy cells and D-stellate cells.

Main Results:

  • Bimodal auditory-Sp5 stimulation enhanced envelope coding at low modulation frequencies.
  • This enhancement persisted for up to 45 minutes post-stimulation.
  • Amplitude modulation detection thresholds improved 45 minutes after bimodal stimulation.

Conclusions:

  • Somatosensory input via Sp5 neurons enhances temporal coding in bushy cells.
  • This enhancement is mediated by both direct excitatory and indirect inhibitory projections.
  • Multisensory integration in the cochlear nucleus may improve the perception of communication signals.