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Associations between ABCG2 gene polymorphisms and gefitinib toxicity in non-small cell lung cancer: a meta-analysis

Lina Tang1, Chunling Zhang2, Hairong He3

  • 1Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an, China.

Oncotargets and Therapy
|February 15, 2018
PubMed
Abstract

Insights

The ABCG2 G34A gene variant may predict skin toxicity in non-small cell lung cancer patients treated with gefitinib. However, the ABCG2 C421A polymorphism is not a reliable toxicity marker. Further studies are needed.

Area of Science:

  • Pharmacogenomics
  • Oncology
  • Molecular Biology

Background:

  • Gefitinib is a common treatment for non-small cell lung cancer (NSCLC).
  • Gefitinib is eliminated by the ABCG2 transporter, whose function can be affected by gene polymorphisms.
  • Previous studies on ABCG2 polymorphisms and gefitinib toxicity have yielded conflicting results.

Purpose of the Study:

  • To investigate the association between ABCG2 gene polymorphisms and gefitinib-induced toxicity in NSCLC patients.
  • To clarify the conflicting findings from previous research through a meta-analysis.

Main Methods:

  • Systematic literature search of PubMed and EMBASE databases.
  • Meta-analysis of data from eligible studies.
  • Calculation of relative risk and 95% confidence intervals to assess associations.

Main Results:

  • Seven studies with 515 patients were included.
  • No significant association was found between ABCG2 C421A polymorphism and gefitinib toxicity.
  • The ABCG2 G34A polymorphism was associated with an increased risk of skin toxicity (RR=1.54, P=0.02).

Conclusions:

  • The ABCG2 G34A genotype may predict gefitinib-induced skin toxicity in NSCLC patients.
  • The ABCG2 C421A polymorphism is unlikely to be a reliable marker for gefitinib toxicity.
  • Larger-scale studies are required to validate these findings.
Keywords:
ABCG2NSCLCgefitinibmeta-analysispolymorphismtoxicity

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