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Relationship between etanercept and thyroid function in patients with psoriasis vulgaris
Iulia Ioana Roman1, Teodora Mocan2, Meda-Sandra Orasan2
1Physiology Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.
Clujul Medical (1957)
|February 15, 2018
Summary
Psoriasis treatment with anti-tumor necrosis factor-alpha (TNF-alpha) therapy showed no significant impact on thyroid function. However, a negative correlation was observed between TNF-alpha levels and thyroid-stimulating hormone (TSH).
Area of Science:
- Immunodermatology
- Endocrinology
- Clinical Research
Background:
- Psoriasis vulgaris is a chronic inflammatory skin condition requiring long-term management.
- Tumor necrosis factor-alpha (TNF-alpha) is a key target in psoriasis therapy and may influence thyroid disorders.
- Understanding the interplay between anti-TNF-alpha therapy and thyroid parameters is crucial for patient management.
Purpose of the Study:
- To investigate the relationship between anti-TNF-alpha therapy and thyroid function in patients with psoriasis vulgaris.
- To assess serum levels of triiodothyronine (T3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and antithyroidperoxidase antibody (AbTPO) in treated and untreated psoriasis patients.
- To explore correlations between TNF-alpha levels and thyroid parameters.
Main Methods:
- A cohort of 44 patients with psoriasis vulgaris was studied, including 20 on etanercept (anti-TNF-alpha therapy) and 24 controls.
- Serum concentrations of T3, FT4, TSH, AbTPO, and TNF-alpha were measured.
- Thyroid ultrasonography was performed for all participants.
Main Results:
- Mean serum FT4 levels were significantly higher in patients without systemic treatment (p<0.05).
- Patients receiving etanercept exhibited significantly higher serum TNF-alpha levels (p<0.05).
- A significant negative correlation was found between serum TNF-alpha and TSH levels (r=-0.366, p=0.015).
Conclusions:
- Anti-TNF-alpha therapy in psoriasis patients did not significantly alter most thyroid parameters, except for a higher FT4 in untreated individuals.
- A notable negative correlation exists between serum TNF-alpha and TSH levels.
- Further research comparing different anti-TNF-alpha therapies is warranted.
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