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Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

Masanori Inaba1, Tatsuya Sakai1, Shun Shinada1

  • 1Division of Molecular Science, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma, 376-8515, Japan.

Beilstein Journal of Organic Chemistry
|February 15, 2018
PubMed
Summary

A new one-pot synthesis method creates perfluoroalkyl-substituted phthalides. This practical approach uses 2-cyanobenzaldehyde and perfluoroalkylsilanes, offering good yields for valuable chemical compounds.

Keywords:
cyclizationfluorinelactonephthalidetrifluoromethylation

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