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Updated: Feb 14, 2026

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Published on: October 17, 2025
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice
Vicki Xie1, Daochen Tong1, Craig T Wallington-Beddoe1,2,3,4
11Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
Background:
Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL).
Methods:
In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF.
Results:
Mice lacking ARF and SphK2 had a significantly reduced incidence of ALL compared mice with wild type SphK2.
Conclusions:
These results show that the role of SphK2 in ALL development is not limited to BCR/ABL1 driven disease extending the potential use of inhibitors of this enzyme to ALL patients whose disease have driver mutations other than BCR/ABL1.
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