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Updated: Feb 14, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Evaluation of Atherosclerotic Plaque in Non-invasive Coronary Imaging
Aeshita Dwivedi1, Subhi J Al'Aref1,2,3, Fay Y Lin1,3
1Dalio Institute of Cardiovascular Imaging, NewYork-Presbyterian Hospital, New York, NY, USA.
Abstract:
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Over the last decade coronary computed tomography angiography (CCTA) has gained wide acceptance as a reliable, cost-effective and non-invasive modality for diagnosis and prognostication of CAD. Use of CCTA is now expanding to characterization of plaque morphology and identification of vulnerable plaque. Additionally, CCTA is developing as a non-invasive modality to monitor plaque progression, which holds future potential in individualizing treatment. In this review, we discuss the role of CCTA in diagnosis and management of CAD. Additionally, we discuss the recent advancements and the potential clinical applications of CCTA in management of CAD.
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