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Published on: January 28, 2020
PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease
Thelma Beatriz González-Castro1, Carlos Alfonso Tovilla-Zárate2, Isela Esther Juárez-Rojop3
1División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, 86205, Tabasco, México.
Aim:
Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis.
Methods:
Odds ratio and the corresponding 95% CI were used to assess the results. We included 7476 CHD patients and 8504 healthy controls. All the statistical analyses were performed by Comprehensive Meta-Analysis software (CMA, version 2.0).
Results:
The Ser311Cys polymorphism decreased susceptibility in the overall population and Asian population to CHD. The His477His polymorphism has a protective role in the overall population; however, the subgroup analysis by ethnicity suggested that in Asian population, His477His might increase the risk of CHD.
Conclusion:
These polymorphisms constitute important predictive indicators of CHD susceptibility.
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