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Photofluorination of Aliphatic C-H Bonds Promoted by the Phthalimide Group
Hiromichi Egami1, Shuya Masuda1, Yuji Kawato1
1School of Pharmaceutical Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Abstract:
Aliphatic C-H fluorination of phthalimide derivatives with Selectfluor was investigated under photoirradiation conditions. The reaction did not require any additive or catalyst and afforded C-H fluorinated products in moderate to good yields. It is likely that the reaction site depends on the C-H bond energy, and this may be the reason for the good to high regioselectivity.
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