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Related Experiment Videos

[Rare side effects of gold].

R Stollenwerk, M Annefeld, F Schilling

    Zeitschrift Fur Rheumatologie
    |May 1, 1986
    PubMed
    Summary

    Parenteral gold salts for rheumatoid arthritis can cause rare side effects, including metallic gold deposits in teeth and skin, reversible neck lymph node swelling, IgA loss, and the appearance of autoantibodies.

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    Area of Science:

    • Rheumatology
    • Pharmacology

    Background:

    • Rheumatoid arthritis management often involves disease-modifying antirheumatic drugs.
    • Parenteral gold salts have been utilized for their anti-inflammatory properties in treating rheumatoid arthritis.

    Observation:

    • This report details rare adverse events associated with parenteral gold salt administration.
    • Observed side effects include metallic gold deposition in dental tissues and skin.
    • Reversible lymphadenopathies in the neck region were also noted.

    Findings:

    • Treatment with gold salts led to a significant loss of Immunoglobulin A (IgA).
    • Gold administration induced the appearance of antinuclear antibodies (ANA) and anti-double-stranded DNA (dsDNA) antibodies.
    • Metallic gold deposition was confirmed in both teeth and skin.

    Implications:

    • These findings highlight the importance of monitoring for rare but significant side effects during gold salt therapy.
    • Understanding these adverse reactions is crucial for patient safety and treatment adjustments in rheumatology.
    • Further research may be warranted to elucidate the mechanisms behind gold-induced autoimmunity and deposition.

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