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Updated: Feb 14, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Sumatriptan iontophoretic transdermal system: A novel approach to migraine-specific therapy
1San Francisco Clinical Research Center, CA.
Abstract:
The sumatriptan iontophoretic transdermal system (TDS) (Zecuity, NuPathe, Malvern, PA), a novel approach to the acute treatment of migraine, circumvents the gastrointestinal tract by using low-level electrical energy to transport sumatriptan across the skin. In clinical trials, sumatriptan TDS has provided consistent drug delivery; rapid relief of migraine headache pain and migraine-related nausea; and an excellent safety profile, with a low incidence of triptan-sensation adverse events. Ease of use/application of sumatriptan TDS by migraineurs during an attack is rated highly. Sumatriptan TDS will provide a convenient, acute migraine-specific therapeutic option to the significant subset of patients for whom oral formulations are suboptimal, particularly those with migraine-related nausea (MRN).
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