An analysis of AAN's evidence-based guideline for IVIg use in neurologic disorders: Provider impact and payer perspectives
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Updated: Aug 12, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Saty Satya-Murti1, Katie M Shepard1, Joel M Kaufman1
1Health Policy Consultant (SS-M), Santa Maria, CA; American Academy of Neurology (KMS), Minneapolis, MN; and Department of Neurology (JMK), Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI.
Abstract:
Health insurers look for reliable, published evidence such as evidence-based guidelines put forth by medical specialty societies to craft their coverage policies. These guidelines generate both beneficial and controversial consequences on policies. Coverage policies aim to address the most typical clinical presentations. The American Academy of Neurology guideline for IV immunoglobulin strengthens the case for coverage when it is used to treat Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. The guideline is less likely to strengthen coverage for several other diagnoses with lower levels of evidence. The responsibility to clarify specific situations when patient need falls outside of what is considered to be routine evaluation or treatment rests heavily on the physician. Advice on appealing an unfavorable coverage decision is also provided to the reader.
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