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Updated: Feb 14, 2026
06:27
Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
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Two-Year Neurodevelopment and Growth Outcomes for Preterm Neonates Who Received Low-Dose Intravenous Soybean Oil.
Margaret L Ong1, Isabell B Purdy2, Orly L Levit3
1David Geffen School of Medicine, University of California, Los Angeles, California, USA.
JPEN. Journal of Parenteral and Enteral Nutrition
|February 15, 2018
Summary
Reducing soybean oil (SO) in preterm neonates did not harm neurodevelopment or growth. A lower SO dose showed a potential cognitive benefit at 12 months, but more research is needed.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Clinical Research
Background:
- Intravenous soybean oil (SO) dose may influence intestinal failure-associated liver disease.
- The impact of reduced SO on neurodevelopment (ND) and growth in preterm infants is not well understood.
Purpose of the Study:
- To investigate the effect of varying soybean oil (SO) doses on neurodevelopment (ND) and growth in preterm neonates up to two years of age.
Main Methods:
- A prospective, single-site follow-up study randomized neonates (gestational age ≤29 weeks) to low-dose (LOW) or standard-dose (CON) SO.
- Neurodevelopment was assessed using Bayley Scales of Infant Development III, and anthropometric measurements were taken at 6, 12, and 24 months corrected gestational age.
Main Results:
- Thirty preterm neonates completed follow-up (15 in LOW, 15 in CON).
- No significant differences in overall neurodevelopment (ND) or growth were observed between the LOW and CON groups.
- The LOW SO group showed a statistically significant higher cognitive scaled score at the 12-month follow-up (P = .02).
Conclusions:
- Reduced soybean oil (SO) dosage appears safe regarding neurodevelopment (ND) and growth in preterm infants.
- Larger studies are required to confirm the long-term safety and efficacy of reduced SO dosing strategies before clinical adoption.
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