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Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion: A case report

Jing Huang¹, Yiming Yu, Wei Lin

¹Department of Pharmacy, The Affiliated Hospital of Medical School of Ningbo University Department of Respiratory Medicine, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.

|February 15, 2018

Abstract

Rationale:

Eosinophilic pleural effusion (EPE) is an eosinophil count ≥10% in pleural effusion, which is a rare condition in drug therapy.

Patient Concerns:

We describe the case of a 70-year-old Alzheimer patient who was taking olanzapine for 2 months for the treatment of depression, and developed peripheral eosinophilia and bilateral EPE.

Diagnoses:

Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion was diagnosed.

Interventions:

Olanzapine was discontinued, and repeated drainage of fluid from the pleural cavity was performed.

Outcomes:

All symptoms-as well as the EPE-were resolved 6 months later.

Lessons:

This case is a reminder that olanzapine may be a potential agent for EPE, and that this should be considered in clinical practice.

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