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Antigen-presenting cells in human decidual tissue.

J R Oksenberg, S Mor-Yosef, E Persitz

    American Journal of Reproductive Immunology and Microbiology : AJRIM
    |July 1, 1986
    PubMed
    Summary
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    Decidual antigen-presenting cells (DAPCs) effectively support human T lymphocyte responses, matching peripheral blood antigen-presenting cells (PAPCs) in stimulating immune activity and alloreactivity.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Human T lymphocyte responses are crucial for adaptive immunity.
    • Antigen-presenting cells (APCs) play a vital role in T cell activation.
    • Decidual APCs (DAPCs) and peripheral blood APCs (PAPCs) are key cell types in immune regulation.

    Purpose of the Study:

    • To compare the immune-stimulating capacity of DAPCs and PAPCs.
    • To investigate the role of human lymphocyte antigen (HLA) class II in DAPC function.
    • To analyze the alloreactive and auto-reactive potential of decidual APCs.

    Main Methods:

    • Isolation of DAPCs and PAPCs from human decidual tissue and peripheral blood.
    • Stimulation of T lymphocytes with DAPCs and PAPCs pulsed with various antigens.
    • Assessment of T cell proliferation and reactivity.

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  • Inhibition studies using anti-HLA class II antibodies and ultraviolet radiation.
  • In vitro generation of alloreactive T cells and subsequent stimulation assays.

    • Main Results:

    • DAPCs demonstrated equivalent T cell proliferation to PAPCs when pulsed with antigens.
    • DAPCs exhibited the capacity to stimulate both auto- and alloreactivity.
    • Anti-HLA class II antibody and UV treatment significantly inhibited accessory cell function in both DAPCs and PAPCs.
    • Primed DAPCs stimulated only HLA class II-compatible T lymphocytes.

    Conclusions:

    • Decidual antigen-presenting cells possess potent immune-stimulatory functions comparable to peripheral APCs.
    • HLA class II molecules are critical for the accessory cell function of DAPCs.
    • DAPCs can effectively prime T lymphocytes in an HLA-restricted manner, suggesting a role in maternal-fetal immune interactions.