Computer tomography-based body surface area evaluation for drug dosage: Quantitative radiology versus anthropomorphic
Antoine Iannessi1, Hubert Beaumont2, Christophe Hebert3
1Department of Radiology, Centre Antoine Lacassagne, Nice, France.
Plos One
|February 15, 2018
Summary
A new method for measuring body surface area (BSA) using CT images (iBSA) offers improved accuracy for chemotherapy dosing. This approach enhances precision in oncology, potentially impacting patient treatment plans and body composition analysis.
Area of Science:
- Radiology and Medical Imaging
- Oncology
- Biomedical Engineering
Background:
- Body surface area (BSA) is crucial for accurate chemotherapy dosing in oncology.
- Current BSA calculation models have demonstrated questionable performance and reliability.
- Standardized BSA measurement is essential for optimizing patient treatment.
Purpose of the Study:
- To introduce and validate a novel method for measuring BSA from whole-body CT images, termed iBSA.
- To assess the accuracy and precision of iBSA measurements.
- To evaluate the impact of iBSA on chemotherapy dosage planning compared to traditional methods.
Main Methods:
- Evaluated iBSA accuracy and precision using phantom and CT test-retest images.
- Compared iBSA with the Du Bois and Du Bois model using retrospective PET-CT scans.
- Simulated the effect of iBSA on capecitabine chemotherapy dose planning.
Main Results:
- iBSA demonstrated high precision (standard deviation 1.11%) and accuracy (mean error 1.53%).
- Significant inter-method variability was observed between iBSA and the Du Bois model (standard deviation 4.11%).
- Utilizing iBSA resulted in a 32.5% reclassification rate for capecitabine chemotherapy doses.
Conclusions:
- iBSA offers a standardized and reliable method for BSA assessment in oncology.
- The iBSA approach can significantly impact chemotherapy dose planning, improving accuracy.
- iBSA holds potential for comprehensive body composition analysis and monitoring metabolic changes.
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