[Hemostaseologic study in the use of midazolam-ketamine]

The combination of derivatives of benzodiazepine and analgetics is used now routinely in clinical situations. In former investigations we studied the effect of these drugs on substrates and enzymes of glycolysis and metabolism of lipids, whereby we focused our interest on changes of phosphofructokinase activity. The aim of this study was to monitor the influence of anaesthesia on parameters of haemostasis (Kallikrein-kinin-system, coagulation, fibrinolysis and several proteinase inhibitors). Therefore plasma samples of patients undergoing diagnostic endoscopy were analysed. For anaesthesia a combination of midazolam and ketamine was used.