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Correlation between epicardial fat thickness and aortic valve sclerosis
Maryam Nabati1, Maryam Favaedi2, Masoud Kheirgoo2
11 Department of Cardiology, Cardiovascular Research Center, Faculty of Medicine, 92948 Mazandaran University of Medical Sciences , Sari, Iran.
Asian Cardiovascular & Thoracic Annals
|February 16, 2018
Summary
Increased epicardial fat thickness, a marker of visceral fat, is linked to aortic valve sclerosis. This finding suggests epicardial fat promotes inflammatory changes in the aortic valve.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Metabolic Syndrome
Background:
- Epicardial fat, a visceral fat deposit, secretes proinflammatory and proatherogenic cytokines.
- Previous research indicates an association between aortic valve sclerosis and coronary artery disease.
Purpose of the Study:
- To determine the correlation between epicardial fat thickness and aortic valve sclerosis.
Main Methods:
- 225 patients undergoing coronary angiography for new-onset angina were studied.
- Transthoracic echocardiography was used to measure epicardial fat thickness.
- Aortic valve sclerosis, left ventricular ejection fraction, and diastolic function were assessed.
Main Results:
- Patients with epicardial fat thickness ≥7 mm were older and had higher rates of hypertension and hyperlipidemia.
- These patients exhibited a significantly higher average aortic valve sclerosis score index.
- Lower left ventricular ejection fraction and early mitral annular velocity were observed in patients with greater epicardial fat thickness.
Conclusions:
- Epicardial fat thickness is correlated with aortic valve sclerosis.
- Epicardial fat may play a role in the inflammatory and atherosclerotic changes of the aortic valve.
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