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Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method

Yuan Wei1, Li Yang2, Xiaoyan Zhang2

  • 1School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China (Y.W., L.Y., X.Z., D.S., C.W., K.W.); MtC BioPharma Co. Ltd., Nanjing, Jiangsu, China (M.S.); and Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China (D.G., H.W.) ywei@ujs.edu.cn.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|February 16, 2018
PubMed
Summary

Researchers created a CYP2C11-null rat model using CRISPR/Cas9 gene editing. This model revealed CYP2C11

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