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Updated: Feb 14, 2026

Bilaminar Co-culture of Primary Rat Cortical Neurons and Glia
Published on: November 12, 2011
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
Junsheng Fan1,2, Tszhei Fong1, Xinjie Chen3
1Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Abstract:
Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases.
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