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The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

Lilla Hornyák1, Nikoletta Dobos2, Gábor Koncz3

  • 1MTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Frontiers in Immunology
|February 16, 2018
PubMed

Insights

Indoleamine-2,3-dioxygenase 1 enzyme (IDO1) inhibitors show promise for cancer therapy by modulating the immune response. This review explores IDO1

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Tumors exhibit distinct genetic, epigenetic, metabolic, and immune profiles compared to normal tissues.
  • Molecular compounds modulating anti-neoplasm immunity offer novel cancer treatment strategies.
  • Indoleamine-2,3-dioxygenase 1 (IDO1) enzyme inhibitors are a key therapeutic avenue for inhibiting tumor progression.

Purpose of the Study:

  • To examine the biochemical function of IDO1 in tumor metabolism and immune evasion.
  • To review current diagnostic and therapeutic strategies for IDO-expressing cancers.
  • To enhance immunotherapy efficacy in aggressive cancers.

Main Methods:

  • Biochemical analysis of IDO1's role in cancer.
  • Review of diagnostic tools for IDO expression.
  • Assessment of therapeutic approaches targeting IDO1.

Main Results:

  • IDO1 plays a crucial role in tumor immune evasion and metabolism.
  • IDO1 expression is linked to aggressive and treatment-resistant cancers.
  • Targeting IDO1 can potentially enhance anti-cancer immunotherapy effectiveness.

Conclusions:

  • IDO1 is a significant target for developing novel cancer immunotherapies.
  • Further research into IDO1 inhibitors may lead to improved treatments for difficult-to-treat cancers.
  • Combined therapeutic strategies involving IDO1 inhibition show potential for greater clinical impact.
Keywords:
cancer diagnosticsclinical trialgene expressionimmune surveillanceimmunotherapyindoleamine-2,3-dioxygenasemetabolism

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