Related Experiment Video
Updated: Feb 14, 2026

A Technique for Subcutaneous Abdominal Adipose Tissue Biopsy via a Non-diathermy Method
Published on: September 30, 2017
Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function
Juan Liu1, Jianbin Liu2,3, Hai Li1
1Endocrinology Department, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Objective:
To investigate the relationship between abdominal adipose tissue distribution, β-cell function, and insulin sensitivity (IS) in a Chinese population.
Methods:
One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and 1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were studied. HOMA-IR, HOMA-B, Matsuda index, early- (I0-30/G0-30) and late-phase (I30-120/G30-120) insulin responses and the corresponding disposition indexes (DI) were calculated. The area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) was measured and the ratio of ASAT to VAT (SVR) was calculated.
Results:
SVR was correlated positively with Matsuda index in healthy, MD, and hyperglycemia groups, and inversely with HOMA-IR. SVR positively related with both early- and late-phase DI in the healthy group only. In the healthy group, the hyperbolas of I0-30/G0-30 and I30-120/G30-120 versus Matsuda index in the highest quarter of SVR were significantly right shifted compared to those in the lowest (both P < 0.05).
Conclusions:
In healthy adults, higher SVR was a protective factor for β-cell function and IS, while in those with glucometabolic abnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2 diabetes development.
Related Concept Videos
Epithelial Tissues and Their Functions
Epithelial tissues provide the body's first line of protection from physical,...
Functions of Connective Tissues
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
Impact of Individuals on Individuals
Abdominal Aorta
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Plant Cells and Tissues
Poisson's Ratio

