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Updated: Feb 14, 2026
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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
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Sleep disordered breathing in motor neurone disease
Rebecca F D'Cruz1,2, Patrick B Murphy1,3, Georgios Kaltsakas1
1Lane Fox Respiratory Unit, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Journal of Thoracic Disease
|February 16, 2018
Summary
Motor neurone disease (MND) significantly impacts respiratory function, leading to sleep disordered breathing (SDB). Early identification and non-invasive ventilation (NIV) management of SDB in MND patients improve quality of life and survival.
Area of Science:
- Neurology
- Respiratory Medicine
- Sleep Medicine
Background:
- Motor neurone disease (MND) is a progressive neurodegenerative condition characterized by motor neuron loss.
- MND leads to muscle weakness, including respiratory muscles, causing significant morbidity and mortality.
- Sleep disordered breathing (SDB) is common in MND and precedes overt respiratory failure.
Purpose of the Study:
- To review respiratory muscle function assessments in MND.
- To discuss the types and impact of SDB in MND patients.
- To examine the benefits of non-invasive ventilation (NIV) for SDB in MND.
Main Methods:
- Review of literature on respiratory function, SDB, and NIV in MND.
- Analysis of the impact of SDB on quality of life and prognosis.
- Evaluation of current management strategies for SDB in MND.
Main Results:
- Respiratory muscle weakness is an early feature of MND, contributing to SDB.
- SDB significantly affects patient quality of life and survival in MND.
- Non-invasive ventilation (NIV) has been shown to improve outcomes for MND patients with SDB.
Conclusions:
- Early detection and management of SDB are critical for improving outcomes in MND.
- Non-invasive ventilation (NIV) is a key intervention for managing SDB in MND.
- Further research into respiratory support strategies for MND is warranted.
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