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Updated: Feb 14, 2026
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Persistent mania following cessation of corticosteroids
1Asssociate Professor of Psychiatry, Sydney Adventist Medical School, University of Sydney, Sydney, NSW, Australia.
Summary
Manic symptoms can persist for months after discontinuing corticosteroids. This study highlights the need for active treatment of corticosteroid-induced mania, even after drug cessation.
Area of Science:
- Psychiatry
- Endocrinology
Background:
- Corticosteroids are widely used medications with known psychiatric side effects.
- Manic symptoms are a recognized, though less common, adverse effect of corticosteroid use.
Observation:
- Two elderly patients presented with persistent manic symptoms for several months post-corticosteroid cessation.
- Thorough investigation ruled out other potential causes for the mania.
Findings:
- Both patients responded well to mood-stabilizing medications, including sodium valproate and quetiapine.
- Symptom resolution was sustained at one-year follow-up after gradual medication tapering.
Implications:
- Persistent manic symptoms after corticosteroid withdrawal require active pharmacological management.
- This suggests a potential for prolonged neurobiological changes induced by corticosteroids, necessitating ongoing psychiatric care.
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