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Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

Shikun Yang1, Aimei Li1, JianWen Wang1

  • 1Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Current Medicinal Chemistry
|February 16, 2018
PubMed
Abstract

Insights

Vitamin D Receptor (VDR) activation shows promise for treating kidney diseases. Research indicates VDR plays a protective role against renal injury through multiple mechanisms, offering a potential therapeutic target.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) poses a significant health burden with limited treatment options.
  • Emerging evidence suggests Vitamin D Receptor (VDR) activation benefits various renal conditions.

Purpose of the Study:

  • To review the role of VDR in kidney diseases.
  • To explore VDR-targeting therapies for renal conditions.

Main Methods:

  • A systematic literature search was conducted across multiple databases.
  • The search focused on VDR structure, function, its involvement in specific kidney diseases, and VDR-targeted therapies.

Main Results:

  • VDR activation protects against renal injury via mechanisms like suppressing the renin-angiotensin system (RAS), reducing inflammation, and inhibiting fibrosis.
  • Additional benefits include restoring mitochondrial function, suppressing autoimmunity, and preventing renal cell apoptosis.

Conclusions:

  • Vitamin D Receptor (VDR) presents a viable therapeutic target for kidney diseases.
  • Further research into VDR's function in the kidney could lead to effective treatments for renal diseases.
Keywords:
Acute kidney injuryVitamin D receptorchronic kidney diseaserenal injuryrenal osteodystrophyrenal tubular epithelial cell.

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