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Propionibacterium acnes Has Low Susceptibility to Chlorhexidine Digluconate
Keisuke Nakase1, Hanae Fukushima1, Tomoko Yukawa1
11 Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , Tokyo, Japan .
Surgical Infections
|February 16, 2018
Summary
Chlorhexidine digluconate (CHG) showed limited bactericidal activity against Propionibacterium acnes, a common cause of surgical site infections (SSIs). Disinfectant choice and contact time are critical for preventing SSIs from skin bacteria.
Area of Science:
- Microbiology
- Infectious Diseases
- Dermatology
Background:
- Propionibacterium acnes is a significant contributor to surgical site infections (SSIs).
- Effective skin disinfection is crucial for preventing SSIs caused by skin bacteria.
Purpose of the Study:
- To evaluate the susceptibility of clinical isolates of P. acnes and Staphylococcus epidermidis to various disinfectants.
- To determine the minimum bactericidal concentrations (MBCs) of disinfectants against these skin bacteria.
Main Methods:
- Susceptibility testing of P. acnes and S. epidermidis clinical isolates.
- Determination of minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for disinfectants including chlorhexidine digluconate (CHG).
Main Results:
- Some P. acnes strains exhibited high CHG MBCs, exceeding commercial concentrations, indicating reduced susceptibility.
- CHG demonstrated significantly lower MBCs against S. epidermidis compared to P. acnes.
- Other disinfectants like glutaraldehyde and sodium hypochlorite showed effective bactericidal activity against P. acnes at concentrations below their commercial levels.
Conclusions:
- Skin bacteria exhibit varying susceptibilities to disinfectants.
- Disinfectant selection and application time must ensure bactericidal activity against all potential SSI-causing skin bacteria, including P. acnes.
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