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Propionibacterium acnes Has Low Susceptibility to Chlorhexidine Digluconate

Keisuke Nakase1, Hanae Fukushima1, Tomoko Yukawa1

  • 11 Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , Tokyo, Japan .

Surgical Infections
|February 16, 2018
PubMed
Abstract

Insights

Chlorhexidine digluconate (CHG) showed limited bactericidal activity against Propionibacterium acnes, a common cause of surgical site infections (SSIs). Disinfectant choice and contact time are critical for preventing SSIs from skin bacteria.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Dermatology

Background:

  • Propionibacterium acnes is a significant contributor to surgical site infections (SSIs).
  • Effective skin disinfection is crucial for preventing SSIs caused by skin bacteria.

Purpose of the Study:

  • To evaluate the susceptibility of clinical isolates of P. acnes and Staphylococcus epidermidis to various disinfectants.
  • To determine the minimum bactericidal concentrations (MBCs) of disinfectants against these skin bacteria.

Main Methods:

  • Susceptibility testing of P. acnes and S. epidermidis clinical isolates.
  • Determination of minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for disinfectants including chlorhexidine digluconate (CHG).

Main Results:

  • Some P. acnes strains exhibited high CHG MBCs, exceeding commercial concentrations, indicating reduced susceptibility.
  • CHG demonstrated significantly lower MBCs against S. epidermidis compared to P. acnes.
  • Other disinfectants like glutaraldehyde and sodium hypochlorite showed effective bactericidal activity against P. acnes at concentrations below their commercial levels.

Conclusions:

  • Skin bacteria exhibit varying susceptibilities to disinfectants.
  • Disinfectant selection and application time must ensure bactericidal activity against all potential SSI-causing skin bacteria, including P. acnes.
Keywords:
Propionibacterium acneschlorhexidine digluconateminimum bactericidal concentrationstaphylococcus epidermidissurgical site infection

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