Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.2K
Genetics of Speciation02:16

Genetics of Speciation

22.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
22.0K
What is Population Genetics?01:25

What is Population Genetics?

65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Fast Fourier Transform01:10

Fast Fourier Transform

978
The Fast Fourier Transform (FFT) is a computational algorithm designed to compute the Discrete Fourier Transform (DFT) efficiently. By breaking down the calculations into smaller, manageable sections, the FFT significantly reduces the computational complexity involved. Direct computation of an N-point DFT requires N2 complex multiplications, whereas the FFT algorithm needs only (N/2)log⁡2N multiplications, offering a much faster performance.
The computational efficiency of the FFT becomes...
978
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibiting 15-PGDH restores redox homeostasis and confers neuroprotection in Parkinson's disease.

Redox biology·2026
Same author

Bioprocess Development of a Human Monoclonal Antibody against MERS-CoV: Analytical and Preclinical Studies.

Biomolecules & therapeutics·2026
Same author

Thiazole-Linked <i>N</i>-Hydroxypropanamide Derivatives: Selective HDAC6 Inhibitors with Therapeutic Potential for Neurodegenerative Diseases.

Journal of medicinal chemistry·2026
Same author

Corrigendum to "Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal" [Experimental Neurology, vol. 213,1 (2008): 114-21].

Experimental neurology·2026
Same author

Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia.

Biochemical pharmacology·2026
Same author

Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle.

eLife·2026

Related Experiment Video

Updated: Feb 14, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

9.6K

Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Joonki Kim1,2, Sung-Wook Kang1, Karthik Mallilankaraman1

  • 1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore.

Human Molecular Genetics
|February 16, 2018
PubMed
Summary
This summary is machine-generated.

Intermittent fasting (IF) protects the brain from ischemic stroke by altering gene expression. The 16-hour fasting group (IF16) showed suppressed detrimental pathways and enhanced neuroplasticity genes, unlike ad libitum fed mice.

More Related Videos

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.7K
A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
10:18

A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae

Published on: April 25, 2015

10.7K

Related Experiment Videos

Last Updated: Feb 14, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

9.6K
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.7K
A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
10:18

A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae

Published on: April 25, 2015

10.7K

Area of Science:

  • Neuroscience
  • Genetics
  • Metabolic research

Background:

  • Calorie restriction (CR) and intermittent fasting (IF) are known to extend lifespan and protect against neurodegenerative diseases and stroke.
  • Detailed transcriptomic changes in the brain due to dietary interventions like IF are not well understood.
  • Understanding IF's effects on brain gene expression is crucial for developing new stroke therapies.

Purpose of the Study:

  • To describe the transcriptomic changes in the brains of mice subjected to intermittent fasting (IF).
  • To determine if IF induces protective transcriptomic changes in the brain following an ischemic stroke.
  • To investigate the molecular mechanisms underlying IF's neuroprotective effects against stroke injury.

Main Methods:

  • Mice were assigned to ad libitum feeding (AL) or 12-hour (IF12) or 16-hour (IF16) daily fasting.
  • Mice underwent sham surgery or middle cerebral artery occlusion followed by reperfusion.
  • Genome-wide mRNA expression was analyzed using RNA sequencing on brain tissue harvested at various time points post-ischemia/reperfusion.

Main Results:

  • Ad libitum fed (AL) mice showed sustained upregulation of detrimental genetic pathways after ischemic stroke.
  • The 16-hour fasting (IF16) group exhibited suppressed activation of these detrimental pathways.
  • IF16 mice displayed extensive upregulation of neuroplasticity genes and downregulation of protein synthesis pathways during ischemia, unlike AL mice.

Conclusions:

  • Intermittent fasting (IF), particularly 16-hour fasting, provides a genetic molecular framework for protecting brain cells against ischemic stroke damage.
  • IF modulates key cellular signaling and bioenergetic pathways, offering potential targets for clinical interventions.
  • The study reveals distinct transcriptomic adaptations in the brain under fasting conditions that confer resilience to ischemic injury.