Related Experiment Video

Updated: Feb 14, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Arterial stiffness and subendocardial viability ratio in patients with peripheral arterial disease

Giovanni Scandale1, Gabriel Dimitrov1, Martino Recchia2

  • 1Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy.

Journal of Clinical Hypertension (Greenwich, Conn.)
|February 16, 2018
PubMed

Insights

Arterial stiffness in peripheral arterial disease (PAD) is linked to reduced heart perfusion. This study found that increased arterial stiffness correlates with poorer cardiac perfusion in PAD patients, suggesting a connection to cardiovascular events.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Gerontology

Background:

  • Arterial stiffening is a key indicator of aging and atherosclerosis, particularly in peripheral arterial disease (PAD).
  • Understanding the relationship between arterial stiffness and cardiac function is crucial for managing cardiovascular risk.

Purpose of the Study:

  • To investigate the associations between measures of arterial stiffness and cardiac perfusion indices.
  • To explore these relationships in patients with and without peripheral arterial disease (PAD).

Main Methods:

  • Carotid-femoral pulse wave velocity (c-fPWV), augmentation index corrected for heart rate (Aix@HR75), and subendocardial viability ratio (SEVR) were measured using applanation tonometry.
  • Ankle-brachial index (ABI) was calculated from ankle systolic pressure measurements obtained via Doppler probe.
  • The study included 555 subjects (248 PAD, 307 non-PAD) with a mean age of 63 years.

Main Results:

  • SEVR was not significantly related to c-fPWV or ABI in either PAD or non-PAD groups.
  • In PAD patients, SEVR showed a significant negative association with Aix@HR75 and aortic pulse pressure (PP).

Conclusions:

  • Arterial stiffness, particularly elevated Aix@HR75 and aortic PP, is associated with impaired myocardial perfusion in PAD patients.
  • These findings suggest a potential pathophysiological link between arterial stiffness and increased cardiovascular events in PAD.

Keywords:
arterial stiffnessperipheral arterial diseasesubendocardial viability

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