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Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

15.5K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
15.5K
Classification of Connective Tissues01:30

Classification of Connective Tissues

16.4K
The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
16.4K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

6.6K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
6.6K
Dense Connective Tissue01:13

Dense Connective Tissue

12.5K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
12.5K
Functions of Connective Tissues01:17

Functions of Connective Tissues

17.3K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
17.3K
Loose Connective Tissue01:26

Loose Connective Tissue

10.0K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
10.0K

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A Simplified and Efficient Method to Isolate Primary Human Keratinocytes from Adult Skin Tissue
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Primary anetoderma with undifferentiated connective tissue disease.

Lana X Tong1, Jenna Beasley, Shane Meehan

  • 1New York University Health, New York.

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Summary
This summary is machine-generated.

Anetoderma, a rare skin condition causing elastin loss, presented unusually in a patient with painful, itchy lesions. This case highlights diagnostic challenges and impacts on quality of life for this difficult-to-treat disorder.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Anetoderma is a rare benign elastolytic disorder characterized by focal loss of elastin.
  • It is often recalcitrant to treatment, posing management challenges.

Observation:

  • A patient presented with a 20-year history of pruritic and painful hyperpigmented atrophic papules.
  • Lesions were clustered on the neck, axillae, inframammary folds, and right medial thigh.

Findings:

  • Histopathology of axillary lesions was consistent with anetoderma.
  • The clinical presentation was unusual due to extent, pain, pruritus, and sharp demarcation.

Implications:

  • This case underscores the diagnostic uncertainty and management difficulties associated with anetoderma.
  • Unusual presentations can significantly impact a patient's quality of life, necessitating further research into effective treatments.