Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disorders of neuronal migration: sonographic features.

J Q Trounce, D G Fagan, I D Young

    Developmental Medicine and Child Neurology
    |August 1, 1986
    PubMed
    Summary

    Cranial ultrasound can show features of neuronal migration disorders like lissencephaly and polymicrogyria in neonates. Caution is needed when diagnosing these disorders in premature infants and those with Down syndrome due to potential normalization of scans.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Towards characterization of photo-excited electron transfer and catalysis in natural and artificial systems using XFELs.

    Faraday discussions·2016
    Same author

    Amyloid and the cardiovascular system: A review of pathogenesis and pathology with clinical correlations.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Planned homebirth: not a Dutch treat for export.

    BJOG : an international journal of obstetrics and gynaecology·2014
    Same author

    Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia.

    The Cochrane database of systematic reviews·2007
    Same author

    An ethically justified, clinically comprehensive approach to peri-viability: gynaecological, obstetric, perinatal and neonatal dimensions.

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2007
    Same author

    Cerebral perfusion in infants and neonates: preliminary results obtained using dynamic susceptibility contrast enhanced magnetic resonance imaging.

    Archives of disease in childhood. Fetal and neonatal edition·2003

    Area of Science:

    • Neurology
    • Neonatal Imaging
    • Developmental Neuroscience

    Background:

    • Neuronal migration disorders (NMDs) are a group of congenital abnormalities resulting from the disruption of nerve cell movement during fetal development.
    • Accurate diagnosis of NMDs is crucial for appropriate management and prognosis.
    • Cranial ultrasound is a common imaging modality used in neonates.

    Observation:

    • This study describes the cranial ultrasound findings in two neonates diagnosed with NMDs: lissencephaly and polymicrogyria associated with Pena-Shokeir syndrome type 1.
    • A third infant, born extremely prematurely with Down syndrome, presented with similar ultrasound features suggestive of NMDs.

    Findings:

    • The cranial ultrasound features observed in the neonates with confirmed NMDs were consistent with the known radiological manifestations of these conditions.

    Related Experiment Videos

  • Interestingly, the extremely premature infant with Down syndrome showed transient ultrasound findings that normalized by two weeks of age.

    • Implications:

    • The findings highlight the importance of considering gestational age and chromosomal abnormalities, such as Down syndrome, when interpreting cranial ultrasounds for suspected NMDs.
    • The transient nature of ultrasound findings in some extremely preterm infants and those with Down syndrome underscores the need for cautious diagnosis and potential follow-up imaging.
    • This study contributes to the understanding of the spectrum of cranial ultrasound appearances in neonatal neurological conditions.