Related Experiment Video
Updated: Feb 14, 2026
07:35
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
21.3K
Systems immunology allows a new view on human dendritic cells.
Joachim L Schultze1, Anna C Aschenbrenner2
1Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases and University of Bonn, Sigmund-Freud-Str. 27, 53175 Bonn, Germany.
Seminars in Cell & Developmental Biology
|February 16, 2018
Summary
New technologies precisely define human dendritic cell subsets, crucial for immunity and vaccination. This advance clarifies their roles in health and disease, improving future research.
Area of Science:
- Immunology
- Cell Biology
- Systems Biology
Background:
- Dendritic cells are key antigen-presenting cells linking innate and adaptive immunity.
- Classical methods struggled to precisely define dendritic cell subsets.
- Previous research yielded conflicting results on dendritic cell subpopulations.
Purpose of the Study:
- To report on recent studies applying advanced technologies to human dendritic cells.
- To enable precise definition of human dendritic cell subsets.
- To establish molecular signatures for distinct dendritic cell subsets.
Main Methods:
- Single-cell -omics approaches.
- Multi-colour flow cytometry.
- Mass cytometry.
- Systems biology approaches.
Main Results:
- Unprecedented precision in defining cell population structures.
- Emerging era for detailed dendritic cell subset analysis.
- Application of advanced technologies to human dendritic cells.
Conclusions:
- Precise delineation of human dendritic cell subsets is now achievable.
- Defined molecular signatures will enhance future studies.
- Improved understanding of dendritic cell function in health and disease.
Related Concept Videos
01:23Immunological Memory
17.1K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.1K
01:23Neurons: The Cell Body and the Dendrites
7.4K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
7.4K
01:29Econometric Views (EViews)
606
Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
606
01:27Cranial Bones: Lateral View
7.3K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
7.3K
01:24Revisionist Views of Adolescent and Adult Cognition
319
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
319
01:18Second Order systems II
414
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
414