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Updated: Feb 14, 2026

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
Human in vivo-differentiated monocyte-derived dendritic cells
Tsing-Lee Tang-Huau1, Elodie Segura2
1Institut Curie, PSL Research University, INSERM, U932, 26 rue d'Ulm, Paris, 75005, France; Sanofi, Breakthrough Laboratory, 1 impasse des ateliers, Vitry-sur-Seine, 94400, France.
Abstract:
When entering tissues, monocytes can differentiate into cells that share morphological and functional features with either dendritic cells (DC) or macrophages. Monocyte-derived DC have been observed in humans at mucosal tissues and in inflammatory settings, where they are usually referred to as «inflammatory DC». In this chapter, we review recent studies on the characterization of these cells in humans. We also discuss nomenclature and examine the criteria defining in vivo-differentiated human mo-DC.
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