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Updated: Feb 14, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
15.1K
Histopathological changes resulting from selective internal radiotherapy (SIRT)
Christoph Justinger1, Juliana Gruden2, Konstantinos Kouladouros1
1Department of General and Visceral Surgery, Klinikum Karlsruhe, Karlsruhe, Germany.
Journal of Surgical Oncology
|February 16, 2018
Summary
Selective internal radiotherapy (SIRT) effectively controls liver tumors with minimal healthy tissue damage. Histopathological analysis revealed microspheres in tumors and surrounding tissue, suggesting SIRT aids in preoperative tumor reduction.
Area of Science:
- Hepatobiliary oncology
- Interventional radiology
- Radiation oncology
Background:
- Selective internal radiotherapy (SIRT) is an effective treatment for liver malignancies.
- Histopathological changes in tumors and healthy liver tissue post-SIRT require detailed analysis.
Purpose of the Study:
- To investigate specific histopathological changes in tumor and healthy liver tissues following SIRT and liver resection.
- To evaluate the impact of SIRT on liver tissue and tumor response.
Main Methods:
- Analysis of resected liver tissue from 17 patients who underwent SIRT for liver resectability.
- Microscopic examination of tumor, tumor peripheries, and tumor-free liver tissue.
Main Results:
- Microspheres were detected in tumor beds, tumor-free liver, and portal tracts, with higher concentrations in tumors.
- Most patients exhibited a partial pathological response to SIRT.
- No typical signs of radiation-induced hepatitis were observed in healthy liver tissue.
Conclusions:
- SIRT demonstrates effective tumor control in liver malignancies with minimal adverse effects on healthy liver tissue.
- Observed histopathological changes suggest SIRT's potential role in preoperative downsizing of liver tumors.
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