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Related Experiment Video

Updated: Feb 14, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Histopathological changes resulting from selective internal radiotherapy (SIRT).

Christoph Justinger1, Juliana Gruden2, Konstantinos Kouladouros1

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|February 16, 2018
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Selective internal radiotherapy (SIRT) effectively controls liver tumors with minimal healthy tissue damage. Histopathological analysis revealed microspheres in tumors and surrounding tissue, suggesting SIRT aids in preoperative tumor reduction.

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SIRTliver metastasestumor regression

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Area of Science:

  • Hepatobiliary oncology
  • Interventional radiology
  • Radiation oncology

Background:

  • Selective internal radiotherapy (SIRT) is an effective treatment for liver malignancies.
  • Histopathological changes in tumors and healthy liver tissue post-SIRT require detailed analysis.

Purpose of the Study:

  • To investigate specific histopathological changes in tumor and healthy liver tissues following SIRT and liver resection.
  • To evaluate the impact of SIRT on liver tissue and tumor response.

Main Methods:

  • Analysis of resected liver tissue from 17 patients who underwent SIRT for liver resectability.
  • Microscopic examination of tumor, tumor peripheries, and tumor-free liver tissue.

Main Results:

  • Microspheres were detected in tumor beds, tumor-free liver, and portal tracts, with higher concentrations in tumors.
  • Most patients exhibited a partial pathological response to SIRT.
  • No typical signs of radiation-induced hepatitis were observed in healthy liver tissue.

Conclusions:

  • SIRT demonstrates effective tumor control in liver malignancies with minimal adverse effects on healthy liver tissue.
  • Observed histopathological changes suggest SIRT's potential role in preoperative downsizing of liver tumors.