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Sleep disorders and Parkinson disease; lessons from genetics
Ziv Gan-Or1, Roy N Alcalay2, Guy A Rouleau1
1Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Department of Human Genetics, McGill University, Montréal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.
Sleep Medicine Reviews
|February 17, 2018
Summary
Genetics research is clarifying the link between sleep disorders and Parkinson disease (PD). Understanding this connection may help identify early markers for PD risk and progression.
Area of Science:
- Neuroscience
- Genetics
- Sleep Medicine
Background:
- Parkinson disease (PD) is a common neurodegenerative disorder with increasing prevalence.
- Sleep disorders are frequent non-motor symptoms in PD, appearing in early and advanced stages.
- The exact relationship between sleep disorders and PD pathogenesis remains unclear.
Purpose of the Study:
- To review current knowledge on the genetics of sleep disorders in the context of Parkinson disease.
- To explore the potential of genetic associations to serve as biomarkers for PD.
- To discuss implications for research, diagnosis, and treatment.
Main Methods:
- Review of recent genetic studies on Parkinson disease and sleep-related disorders.
- Comparative genetic analysis between PD and sleep disorders.
- Synthesis of current literature on the topic.
Main Results:
- Advancements in genetic studies provide new insights into the association between sleep disorders and PD.
- Genetic comparisons can help elucidate the role of sleep disorders in PD etiology and progression.
- Certain sleep disorders may serve as early clinical markers for Parkinson disease risk.
Conclusions:
- Genetics plays a crucial role in understanding the link between sleep disorders and Parkinson disease.
- Identifying genetic markers could improve early diagnosis and risk assessment for PD.
- Further research into the genetics of sleep-related disorders is vital for PD management.
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