Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet serotonin uptake in panic disorder.

T R Norman, F K Judd, M Gregory

    Journal of Affective Disorders
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of workpiece curvature on the tool influence function during hemispherical sub-aperture tool glass polishing.

    Applied optics·2021
    Same author

    Mechanisms influencing and prediction of tool influence function spots during hemispherical sub-aperture tool polishing on fused silica.

    Applied optics·2020
    Same author

    Prenatal exposure to betamethasone causes intergenerational impairment of epididymal development in the rat.

    Andrology·2019
    Same author

    Improving comprehensive care in the haemophilia community: building on the HERO Study.

    Haemophilia : the official journal of the World Federation of Hemophilia·2016
    Same author

    Insect transformation with piggyBac: getting the number of injections just right.

    Insect molecular biology·2016
    Same author

    Positive well-being during the menopausal transition: a systematic review.

    Climacteric : the journal of the International Menopause Society·2014
    Same journal

    The longitudinal relationship between co-rumination and depressive symptoms in adolescents: A systematic review and meta-analytic structural equation modeling.

    Journal of affective disorders·2026
    Same journal

    Child-experienced discrimination and parent mental health in Latino families.

    Journal of affective disorders·2026
    Same journal

    Suicide risk prediction and analysis of associated factors among high school students in four provinces of China based on explainable machine learning.

    Journal of affective disorders·2026
    Same journal

    Integrating hypertriglyceridemia, inflammation, and β-cell stress in clozapine- and olanzapine-associated pancreatitis.

    Journal of affective disorders·2026
    Same journal

    Exploring the functioning trajectories and associated factors in adolescents with first-diagnosis major depressive disorder: Evidence from the sBEAD cohort.

    Journal of affective disorders·2026
    Same journal

    Effects of a self-directed cognitive behavioral therapy manual on depressive symptoms among youths incarcerated for drug-related offenses.

    Journal of affective disorders·2026
    See all related articles

    Patients with panic attacks exhibit significantly higher platelet serotonin uptake (Vmax) compared to controls. This suggests a specific abnormality in serotonin transport in individuals experiencing panic attacks.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Psychiatry

    Background:

    • Panic attacks are a significant psychiatric condition.
    • Serotonin is a key neurotransmitter implicated in mood and anxiety disorders.
    • Platelets offer a model system for studying neurotransmitter transport mechanisms.

    Purpose of the Study:

    • To investigate platelet serotonin uptake in patients with panic attacks.
    • To compare serotonin transporter kinetics between panic disorder patients and healthy controls.

    Main Methods:

    • Quantified platelet serotonin uptake using Vmax (maximum velocity) and Km (affinity constant).
    • Compared kinetic parameters between 45 patients with panic attacks and 21 healthy controls.
    • Utilized radioligand binding assays to measure serotonin transporter function.

    Related Experiment Videos

    Main Results:

    • Patients with panic attacks showed significantly higher Vmax values (100.2 +/- 11.5 pmol/10(8) platelets/min) compared to controls (34.9 +/- 3.8 pmol/10(8) platelets/min; P < 0.0005).
    • The affinity constant (Km) for serotonin uptake did not differ significantly between groups.
    • Elevated Vmax (>60 pmol/10(8) platelets/min) was observed in 60% of patients versus 5% of controls.

    Conclusions:

    • Patients with panic attacks demonstrate a specific abnormality in platelet serotonin uptake.
    • The increased Vmax suggests an enhanced capacity for serotonin transport in platelets of panic disorder patients.
    • These findings may indicate altered serotonergic system function in panic disorder.