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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in

Rachel S Newby1, Matthew Dryden2,3, Raymond N Allan1,4

  • 1Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.

Journal of Clinical Pathology
|February 17, 2018
PubMed

Insights

SurgihoneyRO, a novel honey-based treatment, effectively reduces non-typeable Haemophilus influenzae (NTHi) biofilms by releasing hydrogen peroxide. This innovative approach shows greater efficacy than co-amoxiclav for NTHi biofilm infections.

Area of Science:

  • Microbiology and Infectious Diseases
  • Biotechnology and Medical Devices

Background:

  • Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen contributing to chronic respiratory diseases.
  • NTHi biofilms promote persistent infections and antimicrobial resistance, necessitating new therapeutic strategies.
  • Hydrogen peroxide (H2O2) exhibits susceptibility against H. influenzae.

Purpose of the Study:

  • To evaluate the efficacy of SurgihoneyRO, a bioengineered honey product, against established NTHi biofilms.
  • To investigate the mechanism of action involving slow release of H2O2.

Main Methods:

  • Established NTHi biofilms were treated with SurgihoneyRO.
  • Biofilm viability was assessed post-treatment.
  • Comparison was made with the conventional antibiotic co-amoxiclav.

Main Results:

  • SurgihoneyRO significantly reduced NTHi biofilm viability.
  • Enhanced H2O2 production was observed as the primary mechanism.
  • SurgihoneyRO demonstrated superior efficacy compared to co-amoxiclav.

Conclusions:

  • SurgihoneyRO is a promising therapeutic agent for combating NTHi biofilm-associated respiratory infections.
  • The slow release of H2O2 provides an effective strategy against recalcitrant NTHi biofilms.
Keywords:
antimicrobial resistancebacteriologyhaemophilus sppinfection control

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