Related Experiment Video
Updated: Feb 14, 2026

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
Published on: July 25, 2025
CAR-T cells: the long and winding road to solid tumors
Maria Michela D'Aloia1, Ilaria Grazia Zizzari2, Benedetto Sacchetti3
1Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Abstract:
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles.
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