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Updated: Feb 14, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Structural elucidation of a polysaccharide from Flammulina velutipes and its immunomodulation activities on mouse B
Wen-Han Wang1, Jing-Song Zhang1, Ting Feng1,2
1National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding. Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.
Abstract:
A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes. Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR. FVPB2 was a homogeneous heteropolysaccharide (molecular weight ~ 1.50 × 104 Da) containing D-galactose, D-mannose, L-fucose, and D-glucose at molar ratio of 1.9:1.2:1:2.5. In vitro immunomodulatory studies showed FVPB2 induced proliferation of mouse spleen lymphocytes in a dose-dependent manner. The levels of IgM and IgG, secreted by B cells, increased after FVPB2 treatment. So FVPB2 has potential to be a new important immunomodulatory nutraceutical.
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