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Updated: Feb 14, 2026

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A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
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Aflibercept efficacy in refractory choroidal neovascularization
Daniel Constantin Brănişteanu1,2, Andrei Bîlhă3, Andreea Moraru1,3
1Ophthalmology Department, "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
Romanian Journal of Ophthalmology
|February 17, 2018
Summary
Aflibercept (EYLEA®) showed anatomical improvement in 62.5% of patients with refractory choroidal neovascularization (CNV) previously treated with bevacizumab (AVASTIN®). While safe, visual benefits were limited, indicating potential for aflibercept in difficult CNV cases.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vascular Biology
Background:
- Choroidal neovascularization (CNV) can become refractory to anti-VEGF therapies.
- Bevacizumab (AVASTIN®) is a common treatment for CNV.
- Treatment resistance necessitates exploring alternative therapeutic options.
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