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Published on: May 9, 2018
Abstract:
The lack of a tumor-localization aid for transitional cell carcinoma of the bladder and the known cytotoxic effect of light-activated intracellular hematoporphyrin derivative (HpD) prompted the initiation of a trial of HpD photodynamic therapy in patients with focal and diffuse bladder cancer. An argon-ion, pumped-dye laser was used as a source of red light. In 15 patients with focal disease and circumscribed treatment, 3-month follow-up cystoscopic examination showed disappearance of the lesions, but the subsequent recurrence rate seemed high. Therefore, whole-bladder HpD photodynamic therapy was administered to 14 patients with diffuse resistant carcinoma in situ. Three of these patients had focal recurrent disease. The only adverse effects of therapy were cutaneous photosensitivity and bladder irritability. HpD seems to be a good tumor-localizing aid for transitional cell carcinoma of the bladder, and HpD photodynamic therapy effectively destroys this type of carcinoma.
Insights
Hematoporphyrin derivative (HpD) photodynamic therapy shows promise for bladder cancer. This treatment aids tumor localization and effectively destroys transitional cell carcinoma, though recurrence rates require further study.
Area of Science:
- Oncology
- Photodynamic Therapy
- Urologic Oncology
Background:
- Transitional cell carcinoma of the bladder lacks effective tumor-localization aids.
- Hematoporphyrin derivative (HpD) exhibits cytotoxic effects upon light activation.
Purpose of the Study:
- To evaluate HpD photodynamic therapy (PDT) as a tumor-localization aid and treatment for bladder cancer.
- To assess efficacy in both focal and diffuse bladder cancer types.
Main Methods:
- Utilized an argon-ion, pumped-dye laser for red light delivery.
- Administered HpD PDT to patients with focal and diffuse bladder cancer.
- Evaluated treatment outcomes via cystoscopic examination.
Main Results:
- Focal disease treatment showed initial lesion disappearance, but high recurrence rates were observed.
- Whole-bladder HpD PDT in diffuse carcinoma in situ demonstrated effectiveness.
- Adverse effects included cutaneous photosensitivity and bladder irritability.
Conclusions:
- HpD serves as a valuable tumor-localizing agent for transitional cell carcinoma of the bladder.
- HpD photodynamic therapy is an effective modality for destroying transitional cell carcinoma in the bladder.
