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Updated: Feb 14, 2026

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Published on: November 1, 2024
Expression of semaphorin class 3 is higher in the proliferative phase on the human endometrium
Gustavo Dias Ferreira1,2,3, Edison Capp4,5, Julia Jauckus5
1Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. gusdiasferreira@gmail.com.
Purpose:
The semaphorins are related to angiogenesis and cell proliferation depending on the tissue. The purpose of this study was to assess gene expression of class 3 semaphorin (SEMA3A-F) and protein expression of semaphorin 3A (SEMA3A) within human endometrium throughout the menstrual cycle.
Methods:
Gene expression of SEMA3A-F was analyzed by real-time PCR (qRT-PCR) and protein expression of SEMA3A was analyzed by ELISA in endometrial biopsies in the proliferative and secretory phase of the menstrual cycle.
Results:
Gene expression of SEMA3A, SEMA3C, SEMA3D, and SEMA3E was statistically significant decreased in secretory compared to proliferative phase endometrium (p < 0.05). Accordingly, SEMA3A protein expression in the secretory phase was lower than protein expression in proliferative phase endometrium (p ≤ 0.05).
Conclusion:
SEMA3A, 3C, 3D, and 3E are possibly related to cell proliferation in the endometrium, being more expressed in the proliferative phase of the cycle. This finding may stimulate studies of class 3 semaphorins as a possible target for treatment of endometrial pathologies.
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