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Updated: Feb 14, 2026

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Recent progress in dendrimer-based nanomedicine development.

Yejin Kim1, Eun Ji Park1, Dong Hee Na2

  • 1College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.

Archives of Pharmacal Research
|February 17, 2018
PubMed
Summary
This summary is machine-generated.

Dendrimers, unique nanoarchitectures, show promise in nanomedicine for drug delivery and treating cancer, inflammation, and viral infections. Further development is expected for clinical applications.

Keywords:
DendrimerDrug deliveryNanoarchitectureNanomedicineNanotechnology

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Dendrimers possess unique nanoarchitectures: spherical shape, uniform structure, and numerous surface functionalities.
  • These properties enable diverse applications in drug/gene delivery, nanomedicine, diagnostics, and biomedical engineering.
  • Dendrimers can encapsulate or conjugate therapeutic agents, offering targeted delivery and intrinsic therapeutic effects.

Purpose of the Study:

  • To review recent advancements in dendrimer-based nanomedicines.
  • To highlight applications in treating cancer, inflammation, and viral infections.
  • To discuss the advantages of dendrimers over traditional polymers in drug delivery.

Main Methods:

  • Review of current literature on dendrimer applications in nanomedicine.
  • Analysis of dendrimer properties relevant to drug delivery and therapeutic efficacy.
  • Focus on recent developments in dendrimer-based treatments for specific diseases.

Main Results:

  • Dendrimers offer superior drug-loading capacity and precise size control compared to conventional polymers.
  • Multivalency allows conjugation with various molecules, enhancing targeting and sensing capabilities.
  • Significant progress has been made in developing dendrimer-based nanomedicines for major diseases.

Conclusions:

  • Dendrimers present distinct advantages for drug delivery and nanomedicine development.
  • Despite challenges in production and characterization, dendrimer-based therapies show strong potential.
  • Several dendrimer drug candidates are nearing clinical trials, indicating future therapeutic impact.