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Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart

Stanford E Mwasongwe1, Tibor Fülöp2,3, Ronit Katz4

  • 1Jackson Heart Study, Jackson State University, Jackson, MS, USA.

Journal of Clinical Hypertension (Greenwich, Conn.)
|February 17, 2018
PubMed

Insights

Elevated uric acid (UA) is linked to a higher risk of rapid kidney function decline and developing chronic kidney disease (CKD) in African Americans. This study highlights UA as a significant factor in kidney health.

Area of Science:

  • Nephrology
  • Cardiovascular Health
  • Metabolic Disorders

Background:

  • The independent role of elevated uric acid (UA) in the development of chronic kidney disease (CKD) remains unclear.
  • Understanding risk factors for CKD progression is crucial for public health.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and rapid kidney function decline (RKFD) and incident CKD.
  • To evaluate UA as an independent risk factor for kidney disease progression in African Americans.

Main Methods:

  • Longitudinal study of 3702 African Americans from the Jackson Heart Study (JHS).
  • Serum UA levels measured at baseline (2000-2004).
  • RKFD defined as ≥30% eGFR loss; incident CKD defined as eGFR <60 mL/min/1.73 m² with ≥25% eGFR decline by 2009-2013.

Main Results:

  • RKFD and incident CKD observed in 11.4% and 7.5% of participants, respectively.
  • Participants in the highest UA quartile had significantly higher odds of RKFD (OR, 1.8) and incident CKD (OR, 2.00) compared to the lowest quartile, after full adjustment.
  • Elevated UA was significantly associated with both RKFD and incident CKD in the JHS cohort.

Conclusions:

  • Elevated serum uric acid is significantly associated with an increased risk of rapid kidney function decline and incident chronic kidney disease in African Americans.
  • The findings suggest that uric acid may be an independent risk factor for CKD progression.
  • Further research is warranted to explore therapeutic strategies targeting UA to prevent or slow CKD progression.

Keywords:
African AmericanCKD progressionalbuminuriachronic kidney diseaseestimated glomerular filtration raterapid kidney function declineuric acid

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