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Simulating localised cellular inflammation and substrate properties in a strain energy density based bone remodelling
Naomi Rosenberg1, Anthony M J Bull1
1a Department of Bioengineering , Imperial College London , London , UK.
Computer Methods in Biomechanics and Biomedical Engineering
|February 17, 2018
Summary
This study introduces a new computational model for bone remodeling that incorporates inflammation, crucial for trauma repair. The model simulates bone structure formation influenced by trauma distance, stem cell density, and stiffness, offering insights into physiological scenarios.
Area of Science:
- Biomechanics
- Computational Biology
- Tissue Engineering
Background:
- Finite element models exist for bone structure but lack inflammation simulation.
- Inflammation is critical for bone repair following trauma.
Purpose of the Study:
- To develop and test an extended finite element model incorporating inflammation for bone remodeling.
- To simulate bone repair processes influenced by inflammatory factors.
Main Methods:
- Developed a computational model regulating bone remodeling based on inflammation.
- Incorporated parameters: distance from trauma, mesenchymal stem cell density, and substrate stiffness.
- Tested the model on a two-dimensional plate simulation.
Main Results:
- The extended algorithm successfully generated diverse bone structures.
- Model outputs varied based on input parameters, reflecting different physiological conditions.
- Demonstrated the potential to replicate bone remodeling influenced by inflammation.
Conclusions:
- The proposed model effectively integrates inflammation into bone remodeling simulations.
- This approach advances the ability to model bone repair in trauma scenarios.
- The model provides a framework for future research into bone healing and heterotopic ossification.
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