Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Patient-centered Care01:13

Patient-centered Care

3.1K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

280
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
280
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

269
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
269
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

242
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
242
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

279
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
279
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

334
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of cardiovascular fall risk assessment and managment in Dutch fall clinics comparing current practice to guideline recommendations.

European geriatric medicine·2026
Same author

The feasibility of a set of physical resilience measurements in older patients admitted to the acute medical unit.

BMC geriatrics·2025
Same author

Plasma proteome profiling identifies changes associated to AD but not to FTD.

Acta neuropathologica communications·2022
Same author

Influence of Induced Blood Pressure Variability on the Assessment of Cerebral Autoregulation in Patients after Cardiac Arrest.

BioMed research international·2018
Same author

[Treatment of dementia].

Nederlands tijdschrift voor geneeskunde·2017
Same author

[Dementia: growing disaster or declining epidemic?]

Nederlands tijdschrift voor geneeskunde·2017

Related Experiment Video

Updated: Feb 14, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

1.4K

[Orthostatic hypotension in elderly patients].

J A H R Claassen1

  • 1Radboudumc, afd. Klinische Geriatrie en Donders Institute for Brain, Cognition and Behaviour, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|February 17, 2018
PubMed
Summary

Orthostatic hypotension, a blood pressure drop upon standing, is common in the elderly and increases fall risk. Management involves lifestyle changes and medication review.

Area of Science:

  • Geriatrics
  • Cardiology
  • Neurology

Background:

  • Orthostatic hypotension involves inadequate blood pressure recovery after standing, causing temporary reduced cerebral perfusion and increasing fall risk.
  • This condition is most prevalent in the elderly, often stemming from multifactorial causes like reduced circulating volume, peripheral resistance, and limited heart rate increase.
  • Neurogenic orthostatic hypotension specifically results from autonomic dysfunction.

Purpose of the Study:

  • To summarize the causes, contributing factors, and management strategies for orthostatic hypotension, particularly in the elderly population.

Main Methods:

  • Review of literature on orthostatic hypotension, focusing on its pathophysiology, common causes, and drug-induced triggers.
  • Analysis of contributing factors in the elderly, including reduced vascular tone and autonomic regulation.

More Related Videos

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

22.0K
Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.3K

Related Experiment Videos

Last Updated: Feb 14, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

1.4K
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

22.0K
Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.3K
  • Examination of pharmacological agents associated with orthostatic hypotension, such as diuretics, antidepressants, sympatholytics, and vasodilators.

    • Main Results:

    • Orthostatic hypotension is frequently multifactorial in the elderly, involving decreased blood volume, vascular resistance, and heart rate response.
    • Certain medications, including diuretics (if causing hypovolemia), tricyclic antidepressants, alpha- and beta-blockers, and nitrates, can precipitate or exacerbate orthostatic hypotension.
    • Neurogenic orthostatic hypotension is a distinct form linked to autonomic nervous system dysfunction.

    Conclusions:

    • Effective management of orthostatic hypotension in the elderly prioritizes lifestyle modifications, such as rising slowly.
    • Medication review and adjustment are crucial components of treatment, addressing potential iatrogenic contributions.
    • A comprehensive approach considering multifactorial causes is essential for managing elderly patients with orthostatic hypotension.