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Updated: Feb 14, 2026

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant
Published on: September 7, 2016
Fluorescent antitumor titanium(iv) salen complexes for cell imaging
Avia Tzubery1, Naomi Melamed-Book, Edit Y Tshuva
1Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. edit.tshuva@mail.huji.ac.il.
Abstract:
Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.
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