Enhanced glucose sensing based on a novel composite Co^II-MOF/Acb modified electrode

Area of Science:

• Materials Science: Synthesis and characterization of novel metal-organic frameworks (MOFs).
• Electrochemistry: Development of electrochemical sensors for analyte detection.
• Nanotechnology: Fabrication of composite materials for enhanced sensor performance.

Background:

• Metal-organic frameworks (MOFs) offer tunable structures and properties for various applications.
• Electrochemical sensing requires sensitive and selective platforms for accurate analyte quantification.
• Enhancing the electrocatalytic activity of sensing materials is crucial for improving sensor performance.

Purpose of the Study:

• To synthesize and characterize a novel Co^II-based MOF for electrochemical applications.
• To develop an electrochemical sensor for glucose detection using the synthesized Co^II-MOF.
• To improve the sensing performance by creating a composite material with acetylene black.

Main Methods:

• Synthesis of a 2D bilayer Co^II-MOF {[Co₂(Dcpp)(Bpe)_0.5 (H₂O)(μ₂-H₂O)]·(Bpe)_0.5}_n.
• Structural characterization using single-crystal X-ray diffraction.
• Fabrication of modified glassy carbon electrodes (GCE) with Co^II-MOF and Co^II-MOF/acetylene black composites.
• Electrochemical measurements for glucose detection, including sensitivity, linear range, and detection limit determination.

Main Results:

• The Co^II-MOF exhibits a 2D bilayer structure and shows electrocatalytic activity for glucose oxidation.
• The Co^II-MOF/acetylene black composite (Co^II-MOF/Acb) modified electrode demonstrated enhanced glucose sensing.
• The optimal Co^II-MOF/Acb-2%/GCE achieved a high sensitivity (0.255 μA μM^-1 cm^-2), wide linear range (5-1000 μM), and low detection limit (1.7 μM).
• The linear range was extended over tenfold compared to the Co^II-MOF/GCE without acetylene black.
• The sensor exhibited good selectivity and stability.

Conclusions:

• The synthesized Co^II-MOF is a promising material for electrochemical glucose sensing.
• Compositing with acetylene black significantly boosts the electrochemical sensing performance of the Co^II-MOF.
• The Co^II-MOF/Acb-2%/GCE offers a highly sensitive, selective, and stable platform for practical glucose detection.