Related Experiment Video
Updated: Feb 14, 2026
08:27
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
11.4K
Eosinophil-derived exosomes contribute to asthma remodelling by activating structural lung cells
J A Cañas1,2, B Sastre1,2, J M Rodrigo-Muñoz1
1Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Summary
Exosomes from asthmatic eosinophils worsen asthma by damaging lung cells and promoting inflammation. Healthy eosinophil exosomes had no effect, highlighting a specific role in asthma pathogenesis.
Area of Science:
- Immunology
- Cell Biology
- Respiratory Medicine
Background:
- Eosinophils are key in asthma.
- Eosinophils release exosomes.
- The role of eosinophil exosomes in asthma is unclear.
Purpose of the Study:
- To investigate if eosinophil exosomes contribute to asthma.
- To determine if these exosomes activate lung structural cells.
Main Methods:
- Isolated exosomes from asthmatic and healthy donor eosinophils.
- Assessed epithelial cell apoptosis and repair.
- Studied smooth muscle cell proliferation and gene/protein expression.
Main Results:
- Asthmatic eosinophil exosomes increased epithelial apoptosis and impaired repair.
- They also boosted smooth muscle cell proliferation and altered gene expression (e.g., CCR3, VEGFA, CCL26, TNF, POSTN).
- Healthy eosinophil exosomes showed no significant effects.
Conclusions:
- Eosinophil exosomes from asthmatics actively contribute to asthma pathology.
- These exosomes impact structural lung cells, driving disease features.
Related Concept Videos
02:54Nucleosome Remodeling
11.3K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.3K
01:47Lung Capacity
56.5K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.5K
01:28Structures of Carboxylic Acid Derivatives
3.8K
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
3.8K
01:29Asthma-I: Introduction
3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
01:24Asthma-III: Symptoms and Complications
3.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.4K
01:30Asthma-IV: Diagnostic and Management
3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K